Endocrine Abstracts

A 91-year-old lady presented with bradycardia ‘HR ~36, she was alert and conscious initially. Soon after the initial assessment, she was found unresponsive; with blood glucose of 0.8 mmol/l; bradyapnoec; BP 151/59; GCS 5/15; temp ‘32.8°C’. She was aroused after resuscitation with intravenous Dextrose, GCS 15/15 with an element of confusion, the temperature did not exceed 34.9°C despite active warming. The patient looked in a low mood, barely audible, w...

Objective: Pituitary stalk interruption syndrome (PSIS) is a rare congenital abnormality of the pituitary that is responsible for multiple anterior pituitary hormone deficiencies with the estimated incidence of 0. 5/100,000 live births. We report the a case of PSIS from Saudi Arabia.Case report: A 16 year old Saudi boy with short stature and undescended testis, status post bilateral orchidopexy presented to our endocrine clinic. He was delivered by caesa...

We present a case of a 26 years old female who was rushed to hospital with 4 days history of abdominal pain, vomiting and dizziness. She also had one episode of diarrhoea. Further history revealed that she had lost 32 kilograms of weight over the last 18 months through diet and exercise. There were no signs suggestive of an eating disorder.On examination she was peripherally cold, tachycardic (117/min), hypotensive (86/50 mmHg) and sweaty. Her Glasgow Co...

Background: Paragangliomas are extremely rare endocrine tumours and can cause diagnostic difficulty, especially with a coexistent metastatic malignancy.Case: A 78-year-old man with diagnosed metastatic melanoma underwent a PET scan for staging of the malignancy. It showed a left upper quadrant mass with multiple skeletal deposits and a lesion in the pituitary all with intense focal uptake. The mass was unusual for a metastatic lesion from melanoma althou...

Apparent mineralocorticoid excess is a rare syndrome with few reported literature entries. Liquorice tea is a common dietary supplement often used as a slimming aid.We present the case of a 50 year old woman who presented with a two week history of headache, nausea and light sensitivity. Background medical history consisted of irritable bowel syndrome, tubal ligation, thrombosis of a retinal vessel at 17 years of age and a smoker of 10 pack year.<p c...

Introduction: Hypertriglyceridemia is rare but associated cause of pancreatitis and accounts for 10% of cases. Hypertriglyceridemia induced pancreatitis may occur secondary to causes such as diabetes, pregnancy, hypothyroidism and obesity. Management of hypertriglyceridemia includes a change in dietary intake as well as lipid lowering agents, fenofibrates, statins and omega 3 fatty acids. To reduce the triglycerides acutely, intravenous heparin and insulin have been used. In t...

Objectives: We aimed to stratify the possible risk factors for diabetic cardiac autonomic neuropathy (CAN).Methods: We did a metaanalysis of risk factors of CAN. We did a web based search for literature in MEDLINE/PubMed, SCOPUS database, and CENTRAL database up to August 2015. We included clinical trials or cohort studies that provide data about relationship between CAN and variables of interest. Our risk factors of interest were age, sex, duration of d...

Objective: This study was planned to examine the effect of galangin on hyperglycemia mediated oxidative stress in streptozotocin (STZ)-induced diabetic rats.Methods: Diabetes was induced by intraperitoneal administration of low dose of STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 mg/kg BW) or glibenclamide (600 μg/kg BW) was given orally daily once for 45 days to normal and STZ-induced diabetic rats.<p class="abstext...

Introduction: Normal thyroid function is necessary for normal body function. During pregnancy if the thyroid hormone deficiency, it will induce maternal and fetal hypothyroxinemia. And the vulnerable fetuses and neonates will suffer from irreversible deficit in the neuro-psycointellectual development including mental retardation. It is being established that albumin level decreases during pregnancy with recorded increase in urine microalbumin, An elevation in both thyroid stim...

Background: Constitutional delay of growth and puberty (CDGP) is the commonest cause of delayed puberty in boys and differentiation of CDGP from other causes of delayed puberty can sometimes be challenging. We report a boy with delayed puberty due to a pituitary adenoma.Case: A 15-year-old boy was referred for endocrinology consultation with concerns regarding short stature and delayed puberty. There was no history or laboratory evidence suggestive of ch...